Second GTU Photodynamic Day

Hong Boon Lee

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Faculty of Medicine

University of Malaya

Kuala Lumpur, Malaysia

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Hong Boon Lee obtained her BA (1996) and PhD (2000) in Organic Chemistry from the University of Cambridge, UK. She was a Wellcome Trust International Post-doctoral Fellow (2001) at Texas A&M University before joining Cancer Research Initiatives Foundation Malaysia, first as a Post-doctoral Research Scientist (2002), then as Group Leader (2007) of Drug Discovery Research. Since 2014, she joined Faculty of Medicine, University of Malaya as a Senior Research Fellow. Her research interests combine areas of chemistry and biology to discover and develop new anti-cancer drugs and nano-materials, particularly for Photodynamic Therapy.

 

 

 

1.     “Near-infrared activatable phthalocyanine-poly-L-glutamic acid conjugate: increased cellular uptake and light-dark toxicity ratio toward aneffective photodynamic cancer therapy” Kiew LV, Cheah HY, Voon SH, Gallon E, Movellan J, Ng KH, Alpugan S, Lee HB, Dumoulin F, Vicent MJ, Chung LYNanomedicine 2017 Feb 16. pii: S1549-9634(17)30020-5. doi: 10.1016/j.nano.2017.02.002.

2.     “Preclinical safety assessments of nano-sized constructs on cardiovascular system toxicity: A case for telemetry” Cheah HY, Kiew LV, Lee HB, Japundžić-Žigon N, Vicent MJ, Hoe SZ, Chung LY J Appl Toxicol 2017 Feb 6. doi: 10.1002/jat.3437.

3.     “Hemodynamic effects of HPMA copolymer based doxorubicin conjugate: A randomized controlled and comparative spectral study in conscious rats” Cheah HY, Šarenac O, Arroyo JJ, Vasić M, Lozić M, Glumac S, Hoe SZ, Hindmarch CC, Murphy D, Kiew LV, Lee HB, Vicent MJ, Chung LY, Japundžić-Žigon N Nanotoxicology 2017, 11(2), 210-22.

4.     “Tropomyosin Receptor Kinase C Targeted Delivery of a Peptidomimetic Ligand-Photosensitizer Conjugate Induces Antitumor Immune Responses Following Photodynamic Therapy” Kue CS, Kamkaew A, Voon SH, Kiew LV, Chung LY, Burgess K, Lee HB Sci Rep 2016, 6, 37209.

5.     “Iodination improves the phototoxicity of an amphiphilic porphyrin” Topkaya D, Ng SY, Bretonnière Y, Lafont D, Chung LY, Lee HB, Dumoulin FPhotodiagnosis Photodyn Ther 2016, 16,12-4.

6.     “Assessing Biocompatibility of Graphene Oxide-Based Nanocarriers: A Review” Kiew SF, Kiew LV, Lee HB, Imae T, Chung LY J Control Release 2016, 226, 217-28.

7.     “Small Molecules for Active Targeting in Cancer” Kue CS, Kamkaew A, Burgess K, Kiew LV, Chung LY, Lee HB Med Res Rev 2016, 36(3), 494-575.

8.     “A Comparative Study of Cellular Uptake and Subcellular Localization of Doxorubicin Loaded in Self-Assemblies of Amphiphilic Copolymers with Pendant Dendron by MDA-MB-231 Human Breast Cancer Cells” Viswanathan G, Hsu YH, Voon SH, Imae T, Siriviriyanun A, Lee HB, Kiew LV, Chung LY,Yusa SI Macromol Biosci 2016, 16(6), 882-95.

9.     “Antimicrobial activity of a quaternized BODIPY against Staphylococcus strains” Aydın Tekdaş D, Viswanathan G, Zehra Topal S, Looi CY, Wong WF,Min Yi Tan G, Zorlu Y, Gürek AG, Lee HB, Dumoulin F Org Biomol Chem 2016, 14(9), 2665-70.

10.  “Chitosan-coated poly(lactic-co-glycolic acid)- diiodinated boron-dipyrromethene nanoparticles improve tumor selectivity and stealth properties in photodynamic cancer therapy” Siew Hui Voon, Shu Xian Tiew, Chin Siang Kue, Hong Boon Lee, Lik Voon Kiew, Misni Misran, Anyanee Kamkaew, Kevin Burgess and Lip Yong Chung Journal of Biomedical Nanotechnology 2016, 12, 1-22. 

11.  “Targeted PDT agent eradicates TrkC expressing tumors via photodynamic therapy (PDT)” Kue CS, Kamkaew A, Lee HB, Chung LY, Kiew LV, Burgess K Mol Pharm 2015, 12(1), 212-22.

12.  “Preparation of graphene oxide/dendrimer hybrid carriers for delivery of doxorubicin” Siriviriyanun A, Popova M, Imae T, Kiew LV, Looi CY, Wong WF,Lee HB, Chung LY Chemical Engineering Journal 2015, 281, 771-781.

13.  “Ethnomedicinal uses, pharmacological activities, and cultivation of Lignosus spp. (tiger׳s milk mushrooms) in Malaysia - A review” Lau BF, Abdullah N,Aminudin N, Lee HB, Tan PJ J Ethnopharmacol 2015, 169, 441-58.

14.  “Chick embryo chorioallantoic membrane (CAM): an alternative predictive model in acute toxicological studies for anti-cancer drugs” Kue CS, Tan KY,Lam ML, Lee HB Exp Anim 2015,64(2), 129-38.

15.  “In vivo studies of nanostructure-based photosensitizers for photodynamic cancer therapy” Voon SH, Kiew LV, Lee HB, Lim SH, Noordin MI, Kamkaew A, Burgess K, Chung LY Small 2014,10(24), 4993-5013.

16.  “Synthesis of lantadene analogs with marked incitro inhibition of lung adenocarcinoma and TNF-a induced nuclear factor-kappa B (NF-κB) activation” Monika, Sharma A, Suthar SK, Aggarwal V, Lee HB, Sharma M Bioorg Med Chem Lett 2014, 24(16), 3814-8.

17.  “The potential of mycelium and culture broth of Lignosus rhinocerotis as substitutes for the naturally occurring sclerotium with regard to antioxidant capacity, cytotoxic effect, and low-molecular-weight chemical constituents” Lau BF, Abdullah N, Aminudin N, Lee HB, Yap KC, Sabaratnam V PLoS One2014, 9(7), e102509.

18.  “Prioritization of Natural Extracts by LC-MS-PCA for the Identification of New Photosensitizers for Photodynamic Therapy” Norazwana Samat, Pei Jean Tan, Khozirah Shaari, Faridah Abas and Hong Boon Lee Analytical Chemistry 2014, 86(3), 1324-31.

19.  “Novel lung adenocarcinoma and nuclear factor-kappa B (NF-κB) inhibitors: Synthesis and evaluation of lantadene congeners” Sharad Kumar Suthar,Hong L.Boon, Manu Sharma Eur J Med Chem 2014, 74, 135-44.

20.  “Novel dual inhibitors of nuclear factor-kappa B (NF-κB) and cyclooxygenase-2 (COX-2): Synthesis, in vitro anticancer activity and stability studies of lantadene-non steroidal anti-inflammatory drug (NSAIDs) conjugates” Suthar SK, Sharma N, Lee HB, Nongalleima K, Sharma M Current Topics in Med Chem 2014, 14(8), 991-1004.

21.  “Rosamines Targeting the Cancer Oxidative Phosphorylation Pathway” SH Lim, LX Wu, LV Kiew, LY Chung, K Burgess, HB Lee PLoS One 2014,9(3):e82934.

22.  “Improved Photodynamic Efficacy of Zn(II) Phthalocyanines via Glycerol Substitution” Y Chin, SH Lim, Y Zorlu, V Ahsen, LV Kiew, LY Chung, F Dumoulin, HB Lee PLoS One 2014, 9(5):e97894.

23.  “Photodynamic characterization of amino acid conjugated 15(1)-hydroxypurpurin-7-lactone for cancer treatment.” Lim SH, Yam ML, Lam ML,Kamarulzaman FA, Samat N, Kiew LV, Chung LY, Lee HB Mol Pharm 2014, 11(9), 3164-73.

24.  “Chemical Constituents from the bark of Aglaia lanuginose” Fadzly Adzhar Kamarulzaman, Khalit Mohamad, Khalijah Awang, Hong Boon Lee PertanikaJ Sci & Technol 2014, 22(1), 163-74.

25.  “Chemical composition and cellular toxicity of ethnobotanical-based hot and cold aqueous preparations of the tiger's milk mushroom (Lignosus rhinocerotis)” Beng Fye Lau, Noorlidah Abdullah, Norhaniza Aminudin, Hong Boon Lee Journal of Ethnopharmacology Aug 2013, 150(1), 252-62.

26.  “Ternary copper(II)-polypyridyl enantiomers: Aldol condensation, characterization, DNA-binding recognition, BSA-binding and anticancer property” Ng CH, Wang WS, Chong KV, Win YF, Neo KE, Lee HB, San SL, Raja Abd Rahman RN, Leong WK, Dalton Transaction 2013, 42(28), 10233-43.

27.  “Photodynamic Activity of Plant Extracts from Sarawak Borneo” Wan Wui Jong, Pei Jean Tan, Fadzly Adzhar Kamarulzaman, Michele Mejin, DianaLim, Ida Ang, Margarita Naming, Tiong Chia Yeo, Anthony Ho Siong Hock, Soo Hwang Teo and Hong Boon Lee Chemistry & Biodiversity 2013, 10, 1475-86.

28.  “Phylogeny of Asian Homalomena (Araceae) based on ITS region combined with morphological and chemical data” Wong Sin Yeng, Tan Pei Jean, Ng Kiaw Kiaw, Ahmad Sofiman Othman, Lee Hong Boon, Fasihuddin Badruddin bin Ahmad & Peter Charles Boyce Systematic Botany 2013, 38(3), 589-99.

29.   “Synthesis and in vitro anticancer studies of novel C-2 arylidene congeners of lantadenes” Navin K. Tailor, Hong L. Boon, Manu Sharma, European Journal of Medicinal Chemistry 2013, 64, 285–91.

30.  "Effective melanoma inhibition by synthetic pentacyclic triterpenoid 2-(3-phenylprop-2-en-1-ylidene)-22β-hydroxy-3-oxoolean-12-en-28-oic acid: An in vitro and in vivo study " Tailor NK, Lee HB, Sharma M, J Environ Pathol Toxicol Oncol 2013, 32(1), 59-72.

31.  “BODIPY Dyes in Photodynamic Therapy” Anyanee Kamkaew, Siang Hui Lim, Hong Boon Lee, Lik Voon Kiew, Lip Yong Chung, Kevin Burgess Chem. Soc. Rev. 2013, 42(1), 77-88.

32.  "Synthesis, selective cancer cytotoxicity and mechanistic studies of novel analogs of lantadenes" Navin Kumar Tailor, Varun Jaiswal, San Swee Lan,Hong Boon Lee, Manu Sharma, Anticancer Agents Med Chem. 2013, 13(6), 957-66.

33.  “[Zn(phen)(O,N,O)(H2O)] and [Zn(phen)(O,N)(H2O)] with O,N,O = 2,6-dipicolinate and N,O = L-threoninate: synthesis, characterization, biomedical properties" Lee-Fang Chin, Siew-Ming Kong, Hoi-Ling Seng, Yee-Lian Tiong, Kian-Eang Neo, Mohd Jamil Maah, Alan Soo-Beng Khoo, Munirah Ahmad, Tzi-Sum Andy Hor, Hong-Boon Lee, Swee-Lan San, Soi-Moi Chye and Chew-Hee Ng J Biol Inorg Chem 2012, 17(7), 1093-105.

34.  “Two New Phloroglucinol Derivatives and Five Photosensitizing Pheophorbides from Syzygium polyanthum Leaves (Salam)”Har LW, Shaari K, Boon LH, Kamarulzaman FA, Ismail IS Natural Product Communications 2012, 7(8), 1033-6.

35.  “Rapid Identification of Photosensitisers for Photodynamic Therapy using On-Line Hyphenated LC-PDA-MS coupled with photo-cytotoxicity assay” P. J. Tan, D. R. Appleton, M. R. Mustafa, H. B. Lee Phytochemical Analysis 2012, 23(1), 52-9 23(1), 52-9.

36.  “DNA molecular recognition and cellular selectivity of anticancer metal(II) complexes of EDDA and phenanthroline: multiple targets” Sze-Tin Von, Hoi-Ling Seng, Hong-Boon Lee, Seik-Weng Ng, Yusuke Kitamura, Makoto Chikira, Chew-Hee Ng J Biol Inorg Chem 2012, 17(1), 57-69.

37.  “Cyclic Tetrapyrrolic Photosensitisers from Cladophora patentiramea (Cladophoraceae, Chlorophyta) and Turbinaria conoides (Sargassaceae, Phaeophyta) for Photodynamic Therapy” Y.V.Tang, S.M.Phang, W.L.Chu, A.S.H.Ho, S.H.Teo, H.B.Lee Journal of Applied Phycology 2012, 24(4), 783-90.

38.  “Validation of Quantitative Structure-Activity Relationship (QSAR) Model for Photosensitizer Activity Prediction” Neni Frimayanti, Mun Li Yam, Hong Boon Lee, Sharifuddin M. Zain and Noorsaadah Abdul Rahman Int. J. Mol. Sci. 2011, 12, 8626-8644.

39.  “Cyclic Tetrapyrrolic Photosensitisers from the leaves of Phaeanthus ophthalmicus” Pei Jean Tan, Cheng Yi Ong, Asma Danial, Hirzun Mohd Yusof, Bee Keat Neoh, Hong Boon Lee Chemistry Central Journal 2011, 5(1), 32.

40.  “A New Naturally-derived Photosensitiser and Its Phototoxicity on Head and Neck Cancer Cells” Siang Hui Lim, Hong Boon Lee, Anthony Siong Hock Ho Photochemistry and Photobiology 2011, 87(5), 1152-8.

41.  “Derivatives of Pheophorbide-a and -b from Photo-cytotoxic Piper penangense extract Fadzly Adzhar Kamarulzaman, Khozirah Shaari, Anthony Siong Hock Ho, Nordin Haji Lajis, Soo Hwang Teo, Hong Boon Lee Chemistry & Biodiversity 2011, 8(3), 494-502.

42.  “In vitro and In vivo photo-cytotoxicity of BODIPY derivatives for photodynamic therapy” Siang Hui Lim, Cliferson Thivierge, Patrycja Nowak-Sliwinska, Junyan Han, Hubert van den Bergh, Georges Wagnières, Kevin Burgess, Hong Boon Lee Journal of Medicinal Chemsitry 2010, 53(7), 2865-74.

43.  “The Neovessel Occlusion Efficacy of 15-Hydroxypurpurin-7-Lactone Dimethyl Ester Induced with Photodynamic Therapy” Siang Hui Lim, Patrycja Nowak-Sliwinska, Fadzly Adzhar Kamarulzaman, Hubert van den Bergh, Georges Wagnières, Hong Boon Lee Photochemistry and Photobiology 2010, 86, 397-402.

44.  “Incidence and Risk Factors for Cancer in Malaysia” Hong Boon Lee Berita IKM Chemistry in Malaysia 2009, 96, 14.

45.  “The Search for Novel Photosensitisers from Malaysian Plants and Microorganisms” Hong Boon Lee, Nurkhalida Kamal, Cheng Yi Ong, Vikineswary Sabaratnam, Noorlidah Abdullah, Sui Kiong Ling, Rasadah Mat Ali, Anthony S. H. Ho, Soo Hwang Teo Malaysian Journal of Science 2009, 28, 129-45.

46.  “New Cytotoxic Rosamine Derivatives Selectively Accumulate in Mitochondria of Cancer Cells” Siang Hui Lim, Liangxing Wu, Kevin Burgess, Hong Boon Lee Anti-Cancer Drugs 2009, 20(6), 461-8.

47.  “Systematic analysis of in vitro photo-cytotoxic activity in extracts from terrestrial plants in Peninsula Malaysia for photodynamic therapy” Cheng Yi Ong, Sui Kiong Ling, Rasadah Mat Ali, Chin Fei Chee, Zainon Abu Samah, Anthony Siong Hock Ho, Soo Hwang Teo, Hong Boon Lee J. Photochem. Photobiol. B 2009, 96, 216-22.

48.  “Light-activated Cytotoxic Compounds from Malaysian Microorganisms for Photodynamic Therapy (PDT) of Cancer” Nurkhalida Kamal, Vikineswary Sabaratnam, Noorlidah Abdullah, Anthony S. H. Ho, Soo H. Teo and Hong B. Lee Antonie van Leeuwenhoek 2009, 95, 179-88.

49.  “A peptidomimetic of NT-3 acts as a TrkC antagonist” Brahimi F, Malakhov A,  Lee HB, Pattarawarapan M, Ivanisevic L, Burgess K, Saragovi HUPeptides 2009, 30, 1833-9.

50.  “Screening of Red Extracts from Actinomycetes and Fungi for Photodynamic Therapy” C. Y. Ong, S. E. How, S. H. Puah, S. H. Mahassan, K. Suppayah, H. H. Teoh, N. K. Wong, S. H. Teo, A. S. H. Ho, H. B. Lee & C. C. Ho Beyond Medicinal Plants University Publication Centre (UPENA) UiTM2008, 27-34.

51.  “Screening of Selected Species of Malaysian Medicinal Plants for Photodynamic Properties” S. K. Ling, C. F. Chee, H. B. Lee, A. S. H. Ho, M. A. Rasadah, A. S. Zainon, M. G. H. Khoo & A. Norhayati Highlights of FRIM’s Non-IRPA Projects 2006, 53-7.

52.  “p53 status does not affect photodynamic cell killing induced by Hypericin” Lee H.B., Ho A.S.H., Teo S. H. Cancer Chemother. Pharmacol. 2006, 58, 91-8.

53.  “Photo-cytotoxic pheophorbide-related compounds from Aglaonema simplex” Chee C.F., Lee H.B., Ong H.C., Ho A.S.H. Chemistry & Biodiversity2005, 2, 1648-55.

54.  “Selective Small Molecule Peptidomimetic Ligands of TrkA and of TrkC Receptors Afford Discrete or Complete Neurotrophic Activities” M.C. Zaccaro,H. B. Lee, M. Pattarawarapan, Z. Xia, A. Caron, K. Burgess, H. U. Saragovi Chemistry & Biology 2005, 12, 1015-28.

55.  "Syntheses and Activities of New C10 b-Turn Peptidomimetics”  Hong Boon Lee, Maria Clara Zaccaro, Mookda Pattarawarapan, Sudipta Roy, H. Uri Saragovi and Kevin Burgess  J. Organic Chem. 2004, 69, 701-13.

56.  "Syntheses of second generation, 14-membered ring b-turn mimics”  Hong Boon Lee, Mookda Pattarawarapan, Sudipta Roy and Kevin Burgess  Chem. Comm. 2003, 1674-5.

57.  “Syntheses and Spectroscopic Properties of Energy Transfer Systems Based on Squaraines” G. S. Jiao, A. Loudet, H. B. Lee, S. Kalinin, L. B. –A. Johansson, K. Burgess Tetrahedron, 2003, 59, 3109-16.

58.  "Solid Phase Preparation of N-alkyl-N-(b-keto)amides  and 1,2,4,5-Tetrasubstituted Imidazoles Using a Traceless Cleavage Strategy"  H. Boon Lee and Shankar Balasubramanian Organic Lett. 2000, 2, 323-26.

59.  "Studies on a Dithiane-Protected Benzoin Photolabile Safety Catch Linker for Solid-Phase Synthesis" Lee, H. B., Balasubramanian, S. J.  Organic Chem. 1999, 64, 3453-60